Exercise elevates dopamine D2 receptor in a mouse model of Parkinsons disease In vivo imaging with (18F) fallypride (2010)

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Comments: In a mouse model of Parkinson's, treadmill exercise increased dopamine D2 receptors . Addictions cause a decline in D2 receptors which is partly the cause of desensitization. Another reason to exercise.

Movement Disorders

Volume 25, Issue 16, pages 2777-2784, 15 December 2010

Marta G. Vučcković MSc1,2, Quanzheng Li PhD3, Beth Fisher PT, PhD4, Angelo Nacca PhD5, Richard M. Leahy PhD3, John P. Walsh PhD6, Jogesh Mukherjee PhD7, Celia Williams BSc2, Michael W. Jakowec PhD2,4, Giselle M. Petzinger MD2,4*

Abstract

The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [18F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice.

Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [18F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training.

© 2010 Movement Disorder Society