The molecule Delta FosB appears to be the molecular switch for all addictions. Behavioral addictions and drug addictions share common mechanisms and result is similar brain changes. This makes perfect sense as drugs can only amplify or decrease existing physiological mechanisms. The molecule Delta FosB is a transcription factor, which means it turns genes on and off. Pseudoscientific arguments that behavioral addictions are qualitatively different or are “compulsions” rather than addictions, have no basis in hard science. You can find more studies on Delta FosB’s role in addiction here.
- c-Fos, DeltaFosB, BDNF, trkB and Arc Expression in the Limbic System of Male Roman High- and Low-Avoidance Rats that Show Differences in Sexual Behavior: Effect of Sexual Activity (2018)
- Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience (2013)
- Changes in gene expression within the nucleus accumbens and striatum following sexual experience (2005)
- Concurrent exposure to methamphetamine and sexual behavior enhances subsequent drug reward and causes compulsive sexual behavior in male rats (2011)
- Delta JunD overexpression in the nucleus accumbens prevents sexual reward in female Syrian hamsters (2013)
- DeltaFosB in The Nucleus Accumbens is Critical For Reinforcing Effects of Sexual Reward. (2010)
- DeltaFosB Overexpression In The Nucleus Accumbens Enhances Sexual Reward In Female Syrian Hamsters (2009)
- DeltaFosB: A Molecular Switch for Reward (2013)
- Endogenous opioid-induced neuroplasticity of dopaminergic neurons in the ventral tegmental area influences natural and opiate reward (2014)
- Methamphetamine acts on subpopulations of neurons regulating sexual behavior in male rats (2010)
- mGluR5 activation in the nucleus accumbens is not essential for sexual behavior or cross-sensitization of amphetamine responses by sexual experience (2016)
- Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms with ΔFosB as a Key Mediator (2013)
- Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens (2012)
- Neuroplasticity in the Mesolimbic System Induced by Natural Reward and Subsequent Reward Abstinence. (2010)
- Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats (2015)
- Sex experience increases delta FosB in male and female hamsters, but facilitates sex behavior only in females (2019)
- Sex experience increases delta FosB in male and female hamsters, but facilitates sex behavior only in females (2019)
- Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters (2001)
- Sexual experience alters D1 receptor-mediated cyclic AMP production in the nucleus accumbens of female Syrian hamsters (2004)
- Sexual experience in female rodents: cellular mechanisms and functional consequences (2006)
- Sexual experience sensitizes mating-related nucleus accumbens dopamine responses of female Syrian hamsters (1999)
- Sexual reward in male rats: Effects of sexual experience on conditioned place preferences associated with ejaculation and intromissions (2009)
- The Influence of ΔFosB in the Nucleus Accumbens on Natural Reward Related Behavior (2008)
- Ventral Tegmental Area Dopamine Cell Activation during Male Rat Sexual Behavior Regulates Neuroplasticity and d-Amphetamine Cross-Sensitization following Sex Abstinence (2016)